Details of Grant 

EPSRC Reference:	GR/M67292/01
Title:	POLARISED LIQUID-LIQUID INTERFACES IN CHEMICAL ANALYSIS
Principal Investigator:	Arrigan, Professor DWM
Other Investigators:	Dryfe, Professor RAW
Researcher Co-Investigators:
Project Partners:
Department:	Inst for Materials Research
Organisation:	University of Salford
Scheme:	Standard Research (Pre-FEC)
Starts:	01 October 1999	Ends:	30 September 2002	Value (£):	67,411
EPSRC Research Topic Classifications:	Analytical Science
EPSRC Industrial Sector Classifications:	Chemicals Pharmaceuticals and Biotechnology No relevance to Underpinning Sectors
Related Grants:
Panel History:
Summary on Grant Application Form
Charge transfer at liquid-liquid interfaces under electrochemical control has developed rapidly as a topic in fundamental and applied chemical research. Within analytical chemistry, this process has been applied predominantly to ion sensor devices employing amperometric transduction. Facilitated transfers based on crown compound complexation of ions have formed the basis for much of these developments. Calixarenes, macrocycles formed from phenol-formaldehyde condensations, have here-to-fore not been reported for ion-transfer electrochemistry at liquid-liquid interfaces. Likewise, chromatographic separations based on polarised liquid-liquid interfaces have not been reported. By polarising the interface, the transfer of ions from the aqueous phase to the organic phase can be controlled and a degree of selectivity can be imparted to the transfer. Thus separations are possible. We will employ this electrochemical control of ion transfer across the interface in order to develop a new chromatographic technique: liquid-liquid partition chromatography at polarised interfaces, and explore its use in the separations of a range of ionised organic compounds. Various column designs will be explored, employing an immobilised, mechanically-supported organic liquid stationary phase with a flowing aqueous mobile phase. Simple gravity flow chromatographic devices will be employed. Calixarene-facilitated transfers will be explored in our initial experiments.
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Organisation Website:	http://www.salford.ac.uk