| EPSRC Reference: |
GR/M69036/01 |
| Title: |
DECONVOLUTION OF PROTON LCNMR BY MULTIVARIATE METHODS |
| Principal Investigator: |
Brereton, Professor RG |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Bristol |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
30 September 2002 |
Value (£): |
104,952
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| Information Technologies |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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A case study of two closely similar compounds will be chosen in collaboration with industry. LCNMR methods will be developed to balance chromatographic resolution with spectroscopic quality. Chromatographic method development will be required to establish suitable conditions, with special attention paid to economic use of deuterated solvents. A small package will be implemented on a powerful PC to process LC-FTNMR data, inclusive of the problems of data storage. New multivariate methods for deconvolution of LCNMR of mixtures will be established, involving identifying the characteristic NMR peaks, establishing characteristic peaks for each component in the mixture and then, by regression, establishing elution profiles and full spectra for each component in the mixture. Further case studies will be found to obtain a range of quality of chromatograms and spectra.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bris.ac.uk |