| EPSRC Reference: |
GR/M78298/01 |
| Title: |
QUANTIFYING DNA DAMAGE BY ALKYL TRANSFER TO A COBALT SUPERNUCLEOPHILE |
| Principal Investigator: |
Golding, Professor B |
| Other Investigators: |
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| Department: |
School of Chemistry |
| Organisation: |
Newcastle University |
| Scheme: |
ROPA |
| Starts: |
09 February 2000 |
Ends: |
08 February 2001 |
Value (£): |
48,903
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The objective is to develop a new method for studying DNA alkylation by drugs and carcinogens. We will develop reagents for efficient and selective mono-dealkylation of DNA. The method will depend on the transfer of an alkyl group from the phosphotriester to a cobalt (I) supernucleophile. We will study reactions of cob (I) alamin and cobaloxime (I) with nucleotides and DNA modified by alkylating drugs and carcinogens. The product alkylcobalamins will be analysed by HPLC and mass spectrometry, aided by isotopic labelling. The methodology may have important applications in cancer treatment and in monitoring human exposures to carcinogens.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ncl.ac.uk |