| EPSRC Reference: |
GR/M80789/01 |
| Title: |
SYNTHESIS OF MYCAPEROXIDE B. CONSTRUCTION OF THE CYCLIC PEROXIDE VIA A BIOGENETICALLY MODELLED APPROACH |
| Principal Investigator: |
Harwood, Professor LM |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of Reading |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
30 September 2002 |
Value (£): |
80,719
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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To date we have established a flexible route to the carbon skeleton of the anti-tumour, cyclic peroxide containing, sponge norsesterterpene, mycaperoxide B. However, attempts to introduce the peroxide unit, based on a biogenetic route proposed by other workers have failed, calling into question the original proposal. In light of a chemically more plausible proposal we have modified our approach and intend to study its application to completion of the total synthesis. This will require particular attention to stereo- and regio-control. Successful application of this second approach will lend support to the second biogenetic proposal and this methodology can then be applied to the synthesis of closely related members of the mycaperoxide family to confirm somewhat speculative structures based upon sometimes ambiguous analytical data.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.rdg.ac.uk |