| EPSRC Reference: |
GR/M87252/01 |
| Title: |
APPLICATION OF VIBRATIONAL SPECTROSCOPY TO DYNAMICS OF PROTEIN FOLDING ON THE NANOSECOND TIMESCALE |
| Principal Investigator: |
Reid, Dr GD |
| Other Investigators: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1999 |
Ends: |
30 June 2003 |
Value (£): |
165,524
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Structure |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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New experiments have revealed fast protein dynamics in a number of studies and we aim to provide experimental data as input to modern theoretical models. Starting with model peptides and well characterised proteins we shall follow the dynamics of folding using time resolved FTIR spectroscopy. Folding will be triggered using both femtosecond and nanosecond ultraviolet laser pulses and nanosecond temperature jump methods. Changes in the spectrum of the amide I bands during folding will reveal structural information at the molecular level as the peptides begin to collapse and stabilise in the native geometries.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |