| EPSRC Reference: |
GR/M94274/01 |
| Title: |
FUNCTIONAL BIOCOMPATIBILITY & OSTEOLYTIC POTENTIAL OF INTERFACES IN ORTHOPAEDIC IMPLANTS |
| Principal Investigator: |
Fisher, Professor J |
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| Department: |
Mechanical Engineering |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
31 January 2000 |
Ends: |
31 March 2003 |
Value (£): |
368,141
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| EPSRC Research Topic Classifications: |
| Biomaterials |
Tissue Engineering |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Over 80,000 total joint replacements are implanted in the UK every year. Although the short term performance of these devices is good, in the longer term, adverse biological reactions to the wear debris genrated lead to bone resorption and loosening. Over 10% of all joint replacement operations are for revision of failed prostheses, and with an increasing number of prostheses being implanted in younger patients under 65, the development of joint replacements with an osteolysis free life time greater than 20 years is a major aim of the orthopaedic community. Articulating interfaces in joint replacments have traditionally been studied from a mechanical perspective. However the failure mechanisms that limit their lifetimes are interactive, biological and mechanical processes and it is now necessary to focus on the development of prostheses which produce wear debris with reduced biological activity. We aim to develop and evaluate novel biomechanically and tribologically active 3D tissue equivalent cell culture TECC models to study cell/tissue matrix/wear particle interactions. These biological research tools will be applied in a series of strategic research projects aimed at investigating the functional biocompatibility of a range of biomaterials to be used as interfaces in joint replacements.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |