| EPSRC Reference: |
GR/N20928/01 |
| Title: |
A NEW CLASS OF MACROMOLECULES: 2D POLYMERS WITH WELL-DEFINED DIMENSIONS |
| Principal Investigator: |
Huck, Professor W |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
University of Cambridge |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
30 September 2003 |
Value (£): |
63,918
|
| EPSRC Research Topic Classifications: |
| Materials Synthesis & Growth |
|
|
| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
I propose to design and fabricate a new class of 2D polymers by using a (nano)patterned surface as a template. First, a stamping technique (mictocontact printing) will be used to pattern a gold surface into hydrophilic and hydrophobic areas in the 100-500 nm size range. Polymerisable lipids will form a patterned, supported lipid bilayer on these surfaces, which are transformed into ultrathin (<5 nm) polymer sheets (2D polymers). After release from the surface template, the polymers can adopt two different conformations: a collapsed, 3D crumpled state, and a flat, extended 2D phase. It will be possible to add monomers to the bilayer that contain various ligands (sialic acids, mannose, DNA intercalators) to obtain functionalised 2D polymers with affinity for the surface of cells (bacteria), viruses or chromosomes. Conformational changes will then allow the (selective) 'wrapping' of targets in a molecularly thin polymer film.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.cam.ac.uk |