| EPSRC Reference: |
GR/N28696/01 |
| Title: |
TOWARDS NEW RHENIUM AND COPPER BASED RADIOPHARMACEUTICALS |
| Principal Investigator: |
Dilworth, Professor J |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 February 2001 |
Ends: |
30 April 2004 |
Value (£): |
171,859
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Drug Formulation & Delivery |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Healthcare |
| Pharmaceuticals and Biotechnology |
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| Panel History: |
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Summary on Grant Application Form |
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The mechanism of the reduction of [Re04]- with substitute hydrazines will be investigated and developed as a route to new Re complexes in intermediate oxidation states with oxo.diazene and isodiazene cores. A wide range of polydentate ligands will be added to these cores to produce stable complexes which can either be conjugated to biological targeting molecules or have redox/stability characteristics that enable them to target selectively hypoxic cells. In parallel single chain antibody fragments, specific for cancer cell antigens, will be prepared and conjugated using standard methods to new and established Re and Cu complexes. Some new coordination chemistry of copper, together with the extension of some existing chemistry will also be explored with the aim of generating complexes capable of selective reductive trapping in hypoxic cells and tissue. If necessary addition selectivity will be introduced by conjugation to FsVs or hypoxic selective groups such as nitroimidazoles. Complexes with nitrogen mustard related ligands offer the possibility of simultaneous targeted delivery of a cytotoxin and radiation to a tumour site. Radiolabelling protocols will be established for lead Cu and Re complexes and their conjugates and binding, cell uptake (hypoxic selectivity) and biodistribution studies carried out.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ox.ac.uk |