| EPSRC Reference: |
GR/N31702/01 |
| Title: |
BIFURCATING CYCLISATIONS ON PSEUDO C2-SYMMTRIC: SUBSTR ATES: NEW OPPORTUNITIES FOR SELECTIVE DESYMMETRISATIO |
| Principal Investigator: |
Linclau, Professor B |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Sch of Chemistry |
| Organisation: |
University of Southampton |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
30 September 2003 |
Value (£): |
62,334
|
| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
|
|
| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
|
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
The research proposal aims to develop new desymmetrisation methods for symmetric substrates, which could be synthesised by two-directional synthesis. The proposed methods exploit the particular configurational and conformational properties of pseudo C2-symmetric (3.3.0) ring systems, accessible through a conceptually interesting bifurcating cyclisation strategy. We will focus on the synthesis of bis-tetrahydrofuran and pyrrolizidine containing natural products such as (+)-Asteltoxin, (-)-Hastanecine and Rosmarinecine. Initial experiments for the synthesis of highly functionalised tetrahydrofuran rings are included as well.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.soton.ac.uk |