| EPSRC Reference: |
GR/N35014/01 |
| Title: |
DEVELOPMENT OF A SYNTHETIC REPLACEMENT FOR USE IN CARTILAGE REPAIR |
| Principal Investigator: |
Archer, Professor C |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
School of Biosciences |
| Organisation: |
Cardiff University |
| Scheme: |
LINK |
| Starts: |
01 February 2000 |
Ends: |
30 November 2003 |
Value (£): |
425,978
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| EPSRC Research Topic Classifications: |
| Biomaterials |
Tissue Engineering |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Cartilage has a poor reparative potential that has prompted the use of a variety of extrinsic strategies to enhance and facilitate repair. A recurring problem is the lack of integration between reparative tissue and host tissue. Work by use has shown that in part this is due to the immediate responses of cartilage to wounding that evokes an apoptotic response at the wound margin that inhibits integration. We will modulate this response by the use of agents to inhibit apoptosis and growth factors that will up-regulate matrix synthesis. Our industrial partners will develop novel materials that can be implanted into defects that will act as replacement tissue or can be recombined with cells to form a composite. Proof of concept will be carried out on a sheep model that is established at Smith and Nephew.EngProg\
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cf.ac.uk |