Details of Grant 

EPSRC Reference:	GR/N36608/01
Title:	(ROPA) APPLICATION OF ALKENE METHATHESIS TO THE CONCISE SYNTHESIS OF VITAMIN D ANALOGUES
Principal Investigator:	Barrett, Professor T
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	Imperial College London
Scheme:	ROPA
Starts:	01 January 2001	Ends:	31 December 2002	Value (£):	116,129
EPSRC Research Topic Classifications:	Biological & Medicinal Chem.
EPSRC Industrial Sector Classifications:	No relevance to Underpinning Sectors
Related Grants:
Panel History:
Summary on Grant Application Form
The objective of this research is the development of a novel strategy for the synthesis of vitamin D analogues. Such compounds, classically known for their role in regulating calcium metabolism have recently been shown to be relevant to the treatment of cancers, hyperparathyroidism, psoriasis etc. 1a-Hydroxyergocalciferol will be sequentially reacted with alkenyl (dimethyl)silyl chlorides and ruthenium or molybdenum carbenes to produce the corresponding cyclic unsaturated silyl ethers, products of ring closing metatheses. Subsequent deletion of the silyl ether tether by desilylation, oxidation, or palladium (O) catalysed coupling should provide novel vitamin D analogues such as 19-hydroxymethyl -1a-hydroxyergocalciferol.
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Organisation Website:	http://www.imperial.ac.uk