| EPSRC Reference: |
GR/N37674/01 |
| Title: |
CHEMISTRY OF OXIME ESTERS; PREPARATION OF LACTAMS AND RELATED HETEROCYCLES |
| Principal Investigator: |
Walton, Professor JC |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of St Andrews |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
25 September 2000 |
Ends: |
24 September 2003 |
Value (£): |
53,196
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Manufacturing |
Chemicals |
| Food and Drink |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Beta-lactam antibiotics are one of society's most important defences against bacterial infections. 'Cleaner', more environmentally friendly synthetic routes to these compounds are needed and new types are essential because of increasing resistance by microorganisms. This research aims to develop new, cleaner synthetic methods based on oxime ester precursors. These compounds have the potential for photochemical; and/opr thermal preparations, possibly in aqueous media , of existing and new types of beta-lactams. In addition, analogus oxime esters will be used in the preparation of structurally related biologically acyive compounds including gamma-lactams. An explanatory study of homolytic chemistry of hydrazones containing unsaturated side chains will also be undertaken.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.st-and.ac.uk |