| EPSRC Reference: |
GR/N66186/01 |
| Title: |
ROPA: FRET PROBES FOR SELECTIVE IMAGING OF CARCINOMAS |
| Principal Investigator: |
Slater, Professor N |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Department: |
Chemical Engineering and Biotechnology |
| Organisation: |
University of Cambridge |
| Scheme: |
ROPA |
| Starts: |
01 October 2001 |
Ends: |
30 September 2003 |
Value (£): |
113,214
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| EPSRC Research Topic Classifications: |
| Materials Characterisation |
Tissue Engineering |
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Summary on Grant Application Form |
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We propose to design, synthesise and demonstrate macromolecular transponders for sensitive in-vivo imaging. In the preferred application these polymeric probes will passively accumulate at tumour sites. Their pH responsive animation will cause them to hypercoil in the relatively acidic regions of tumours, and in endosomes of tumour cells. The incorporation of multiple near-IR FRET Cy-dye monomers within the backbone of the polymer will provide a highly sensitive and environmentally responsive probe that can be imaged through bodily tissues, so improving optical detection.EngProg\
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cam.ac.uk |