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Details of Grant 

EPSRC Reference: GR/R05154/01
Title: IMI: Activated Carbon Haemoadsorbents For the Removal of Middle Molecular Weight and Other Toxins From Blood
Principal Investigator: Mikhalovsky, Professor S
Other Investigators:
Lloyd, Professor AW Phillips, Dr GJ DAVIES, Dr JG
Researcher Co-Investigators:
Project Partners:
Brighton Health Care NHS Trust Craig Medical Products Ltd Guy's and St Thomas Hospital Trust
Mast Carbon Ltd Purolite
Department: Sch of Pharmacy & Biomolecular Sciences
Organisation: University of Brighton
Scheme: LINK
Starts: 01 January 2001 Ends: 30 June 2004 Value (£): 240,357
EPSRC Research Topic Classifications:
Medical science & disease Separation Processes
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
GR/R03204/01
Panel History:  
Summary on Grant Application Form
This project is focused on synthesis, characterisation and biomedical evaluation of uncoated medical grade activated carbons in the treatment of patients with acute and chronic renal failure. These novel carbons will be used for direct contact with blood and other bodily fluids due their high biocompatibility. It will be achieved by using porous synthetic polymers-precursors with full control over their chemical composition and porous structure followed by control of the carbon surface chemistry to prevent changes in the electrolyte composition of blood brought in contact with the adsorbent.A unique mesoporous structure of carbon adsorbents will be tailor-made to allow fast and efficient adsorption of 'middle-molecules' - substances playing important role in the pathology of renal failure that are not removed efficiently by other methods.Adsorption capacity and kinetics of activated carbons towards uraemic toxins and drugs causing renal failure will be evaluated in vitro and ex vivo from blood, ultrafiltrate and dialysate of acute and chronic renal patients. Target substances include: area, uric acid, creatinine, phosphate, potassium, carbamazepine, ibuprophen, inflammatory cytokines and (2-microglobulin.An extensive evaluation of haemo/biocompatibility of carbons, metods of their sterilisation and storage will be carried out.Efficiency of adsorption devices in-line with other extracorporeal methods will be assessed and a preliminary cost-benefit analysis will be done.
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Further Information:  
Organisation Website: http://www.bton.ac.uk