| EPSRC Reference: |
GR/R15009/01 |
| Title: |
Soft Materials In Tissue Engineering: Relevance of Topography |
| Principal Investigator: |
Riehle, Dr MO |
| Other Investigators: |
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| Department: |
Infection & Immunity |
| Organisation: |
University of Glasgow |
| Scheme: |
Fast Stream |
| Starts: |
01 April 2001 |
Ends: |
31 March 2003 |
Value (£): |
61,625
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Summary on Grant Application Form |
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Cells live in a physically structured world within which most cells are exposed to mechanical deformations and react to topographic and chemical features of their environment by changing it. The interaction between cells and an artificial substrate is essential for any engineered tissue to develop and work properly. One aspect of this interaction is oriented cell growth and motility, which are vital for successful development and wound healing and are believed to be guided by extracellular tracks in vivo. Since microfabrication allows the creation of artificial cellular environments with defined topographic and chemical features itis possible to investigate the significance of these cues. By copying these features into a soft material, which can be deformed by cells it is possible to investigate whether the combination of these cues elicits an effect on cell which can be exploited to aid wound healing and soft tissue implant design.This project aims to investigate and exploit possible synergistic effects occurring when a cell is exposed to an artificial substratum which has topographic features and can be deformed by the cell for the formation of artificial tissues and for a coating for soft tissue implants aimed at reducing fibrous capsule formation.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.gla.ac.uk |