| EPSRC Reference: |
GR/R22674/01 |
| Title: |
Stoichiometric and Catalytic Synthesis of C4-Bridged Diphospines: Applications In Platinum Group Catalysis |
| Principal Investigator: |
Doherty, Dr S |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry and Chemical Eng |
| Organisation: |
Queen's University of Belfast |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 June 2002 |
Ends: |
30 September 2004 |
Value (£): |
122,038
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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BINAP has proven to be an extremely versatile bidentate phosphine which, in combination with an appropriate transition metal, forms catalysts that are highly active and selective for a range of important reactions. However, for reactions that do not involve an asymmetric transformation it would be more practical to find an alternative less expensive but structurally similar diphosphine. The primary aim of this project is to prepare a new class of four carbon bridged diphosphines, the basic structure of which resembles BINAP, to investigate their co-ordination chemistry and undertake a systematic examination of a selection of platinum group catalysed reactions. Achiral and chiral versions of these diphosphines will be prepared and the basic liganc structure will be modified to optimise catalyst performance. A combination of NMR studies and molecular modelling will be used to explore the barrier to interconversion and the relative energy of conformations as a function of substituent. The synthetic methodology will enable us to systematically examine the influence of the C4-tether and phosphine basicity on activity and selectivity within a well-defined range of closely related phosphines. The synthetic protocol has recently been developed in our laboratories and promising results have been obtained in preliminary studies of the application of this new phosphine type in palladium catalysed cross couplings and aminations.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.qub.ac.uk |