| EPSRC Reference: |
GR/R31584/01 |
| Title: |
Advanced Biocompatible Endovascular Stents |
| Principal Investigator: |
Mikhalovsky, Professor S |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Pharmacy & Biomolecular Sciences |
| Organisation: |
University of Brighton |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
30 March 2001 |
Ends: |
29 August 2004 |
Value (£): |
417,497
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| EPSRC Research Topic Classifications: |
| Materials Characterisation |
Materials Processing |
| Medical science & disease |
Tissue Engineering |
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Summary on Grant Application Form |
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The biocompatibility of the currently available coronary stents is compromised by thrombus formation and excessive intimal proliferation leading to in-stent stenosis. In addition the highly corrosive in vivo environment results in gradual release of metal ions into the blood stream. A significant improvement of stent biocompatibility is needed to reduce the rate of intrastent restenosis and target vessel revascularisation. Such an improvement can be achieved either by (1) surface modification of currently existing stents; (2) novel stent design, or by (3) using new materials for stent design. This multi-centered interdisciplinary project involving surface engineers, chemists, cell biologists, material scientists, clinicians and industrial partners aims to address these problems through the development of novel stent coatings with improved biocompatibility. The project will involve an iterative process of stent coatjng and in vitro bioevalaution to determine the relationship between surface interfacial properties and material compatibility in this application. Optimised systems will be evaluated in a limited animal study to provide preliminary data to support subsequent product commercialisation through the industrial partners.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bton.ac.uk |