| EPSRC Reference: |
GR/R36831/01 |
| Title: |
Bioinorganic Chemistry of Triazacyclohexane Complexes. |
| Principal Investigator: |
Kohn, Dr RD |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Bath |
| Scheme: |
Fast Stream |
| Starts: |
01 February 2002 |
Ends: |
31 July 2003 |
Value (£): |
62,280
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Biology |
| Co-ordination Chemistry |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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We have developed the co-ordination chemistry of triazacyclohexanes for several years. During these investigations we have found three areas of bio-inorganic interest. The proposed research shall develop these areas:1) Transition metal clusters can be prepared from simple triazacyclohexane complexes of Cr, Mn, Fe, Co or Ni with weakly co-ordinating ligands by the reaction with precursors to typical cluster bridges. Paramagnetic clusters could be studied by NMR of the rigidly co-ordinated triazacyclohexane.2) We want to study the hydrolysis of simple triazacyclohexane complexes or of the clusters from 1) as potential compounds for the delivery of essential metals into biological systems with an emphasis on chromium.3) Oxygen activation by previously prepared triazocyclohexane copper(I) complexes can be studied analogous to studies on larger ring systems by UV/vis and Raman spectroscopy.Keywords: Co-ordination chemistry, Bioinorganic chemistry.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bath.ac.uk |