| EPSRC Reference: |
GR/R37814/01 |
| Title: |
Effect of Phosphorylation State on Miscibility and Phase Behaviour of Phosphoinositide Lipids |
| Principal Investigator: |
Tiddy, Professor GJT |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chem Eng and Analytical Science |
| Organisation: |
University of Manchester, The |
| Scheme: |
Fast Stream |
| Starts: |
01 June 2001 |
Ends: |
30 September 2004 |
Value (£): |
66,109
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| EPSRC Research Topic Classifications: |
| Complex fluids & soft solids |
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| EPSRC Industrial Sector Classifications: |
| Manufacturing |
Chemicals |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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This proposal concerns a class of lipids, the phosphoinositides, which although comprising only a small percentage of membrane lipids, play a central role in a number of cellular processes. In particular these lipids play a central role in two key signal transduction pathways. It is generally assumed that the phosphoinositides are not homogeneously distributed in the membrane but rather that they form lipid patches through lateral phase separation. This multidisciplinary and collaborative project will focus on the phase behaviour of these highly polar, highly charged compounds and their miscibility with other key membrane lipids. Two complementary approaches will be employed, first an examination of monolayer behaviour and second studies on bulk lipid mesophases and their dispersions (liposomes). The project aims to (i) determine whether phopshoinositides are localized in domains within membranes; (ii) determine the effects of miscibility on membrane structure; and (iii) examine charge, counterion and pH effects on the phase behaviour of these lipids. The results will have implications both in structural surface chemistry, biophysics and, more generally, surfactant behaviour.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.man.ac.uk |