| EPSRC Reference: |
GR/R39689/01 |
| Title: |
New Catalysts for Asymmetric Phospho-Transfer. Exploiting Chirality Relay Effects in Salan Complexes. |
| Principal Investigator: |
Kee, Dr T |
| Other Investigators: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
19 September 2001 |
Ends: |
18 September 2004 |
Value (£): |
86,508
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
Co-ordination Chemistry |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The aim of this work is to develop a new class of chiral metal complex specifically designed to have application in the asymmetric phospho-aldol reaction, the addition of H-phosphonates to carbonyl substrates.The phospho-aldol reaction is an extremely valuable process for [P-C] bond formation and forms the basis for routes to a variety of organophosphorus biomolecules with, for example, antibiotic, antiviral, antitumor and other enzyme inhibition properties.The new class of complex proposed builds upon our recently published example of the first use of chiral salan complexes of aluminium in asymmetric catalysis, these being at present, completely unexplored cousins of the more widely studied salen class of ligand in the context of catalytic applications. Such ligand systems exhibit a form of chirality relay effect seen also in other chiral ligands such as binap and it is our intention to exploit such effects in the design of ligand-metal composites with properties specifically direcetd towards exploitation in the phospho-aldol reaction. Our ultimate objective is h develop catalysts which (i) are air/water compatible, (ii) are tuneable, (iii) are easy to prepare and use under ambient conditions and (iv) deliver high enantioselectivities.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |