| EPSRC Reference: |
GR/R41804/01 |
| Title: |
The pestalotiopsins: New methods, model studies and the first total synthesis. |
| Principal Investigator: |
Procter, Professor DJ |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
School of Chemistry |
| Organisation: |
University of Glasgow |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2001 |
Ends: |
30 September 2004 |
Value (£): |
77,110
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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The aim of this project is to complete the first total synthesis of the pestalotiopsin natural products using innovative chemical methods. Pestalotiopsin A was isolated only recently and has been found to display promising immunosuppressive activity and cytotoxicity in preliminary studies. Furthermore, the complex structure of pestalotiopsin A is unique among natural products and its construction represents a significant synthetic challenge. To date, no synthetic studies on the Pestalotiopisns have been reported in the literature. We wish to apply chemistry recently developed within our group in conjunction with new methods which we will explore during the course of the project, to build the natural products. Our preliminary synthetic studies show our approach is feasible, and that our synthetic goals are achievable in the timescale proposed. The new chemistry and understanding which will arise from our work will prove useful to synthetic organic chemists worldwide.Finally, as a result of our studies, both the natural products themselves, and analogues of them, will be available for biological evaluation.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.gla.ac.uk |