| EPSRC Reference: |
GR/R56457/01 |
| Title: |
Synthesis of Anit-Tumor Acetogenins Cis-Panatellin and Spinencin |
| Principal Investigator: |
Brown, Professor RCD |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Southampton |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2002 |
Ends: |
30 September 2005 |
Value (£): |
78,310
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The research centres on the application of the permanganate oxidation of 1,5,9-trienes, developed in our group, to the synthesis of complex, biologically active natural product targets cis-panatellin and spinencin. An asymmetric version of the oxidation will be developed and used to prepare a key fragment which will form the core of both targets. The use of chemo- and stereoselective methodology will be emphasised in order to minimise the need for extensive protecting group and functional group manipulations, thus streamlining the synthesis.The work will provide the basis for a general approach to many of the biologically active Annonaceous acetogenins, consequently answering stereochemical ambiguities and ultimately providing access to scarce material for biological evaluation. (We have identified individuals willing to carry out the cytotoxicity studies on our synthetic materials).We have also developed a new asymmetric phase-transfer catalysed oxidative cyclisation reaction, and if time permits, we will investigate its application in the synthesis of Annonaceous acegenins.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.soton.ac.uk |