| EPSRC Reference: |
GR/R57492/01 |
| Title: |
Structural Development and Optimisation of Sol-Gel Derived Bioactive Glasses. |
| Principal Investigator: |
Newport, Professor R |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Sch of Physical Sciences |
| Organisation: |
University of Kent |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 May 2002 |
Ends: |
30 April 2004 |
Value (£): |
103,709
|
| EPSRC Research Topic Classifications: |
| Biomaterials |
Materials Characterisation |
|
| EPSRC Industrial Sector Classifications: |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
Comparative studies of various compositions of bioactive glasses, ceramics and glass ceramics have established that there is a considerable range of leve bioactivity, as measured by rates of bone bonding to bulk implants, or the rate of bone proliferation in the presence of bioactive particulates. A very limited range of bioactive glass compositions exhibit a high bioactivity index and bond to both bone and soft connective tissues; the biological response to bioactive gel-glasses made from the Ca0-Si02-P205 system provides evidence that tissue regeneration is possible, at least in bone. A fundamental understanding, the structural development and the relationship of structure to properties are called for: this proposal will apply an advanced chemical physics based mater characterisation methodology to examine a range of biomaterials of fundamental interest. The proposed research programme centres on the exploratory stage of the structural properties of an important set of gel-produced bio-active materials on the atomic (1-101) scale using an extensive characterisationmethodology based upon state-of-the-art MAS NMR equipment and world-class neutron and X-ray facilities. The work will involve in-situ/time-resolved study of key stages in the materials processing, and be explicitly focused on providing an improved understanding of their bio-active properties. This project will concentrate on Ca0-Si02 materials as there are existing medical uses and some fundamental structural questions related to the environment of calcium it silica, with extension to systems with small additions of phosphorus.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.kent.ac.uk |