| EPSRC Reference: |
GR/R57508/01 |
| Title: |
Structural Development and Optimisation of Sol-Gel Derived Bioactive Glasses. |
| Principal Investigator: |
Hench, Professor L |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Materials |
| Organisation: |
Imperial College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 September 2002 |
Ends: |
31 August 2005 |
Value (£): |
58,661
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| EPSRC Research Topic Classifications: |
| Biomaterials |
Materials Characterisation |
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Summary on Grant Application Form |
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Comparative studies of various compositions of bioactive glasses, ceramics and glass ceramics have established that there is a considerable range of levels of bioactivity, as measured by rates of bone bonding to bulk implants, or the rate of bone proliferation in the presence of bioactive particulates. A very limited range of bioactive glass compositions exhibit a high bioactivity index and bond to both bone and soft connective tissues; the biological response to bioactive gel-glasses made from the CaO-SiO2-P205 system provides evidence that tissue regeneration is possible, at least in bone. A fundamental understanding of the structural development and the relationship of structure to properties are called for: this proposal will apply an advanced chemical physics based materials characterisation methodology to examine a range of biomaterials of fundamental interest. The proposed research programme centres on the exploratory study of the structural properties of an important set of gel-produced bio-active materials on the atomic (1-10A) scale using an extensive characterisation methodology based upon state-of-the-art MAS NMR equipment and world-class neutron and X-ray facilities. The work will involve in-situ/time studies of key stages in the materials processing, and be explicitly focused on providing an improved understanding of their bio-active properties This project will concentrate on CaO-SiO2 materials as there are existing medical uses and some fundamental structural questions related to the environment of calcium in silica, with extension to systems with small additions of phosphorus.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.imperial.ac.uk |