| EPSRC Reference: |
GR/R60508/01 |
| Title: |
COST D12 support: The Steroselective Oxidation and Reduction of Heterocycles |
| Principal Investigator: |
Donohoe, Professor T |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
23 April 2002 |
Ends: |
22 April 2005 |
Value (£): |
19,305
|
| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
|
|
| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
The proposed work describes the development of a series of oxidation and reduction reactions as performed on a variety of heterocyclic templates: we have the . goal of developing a set of reactions that provde heavily functionalised heterocyclic templates with complete control of stereochemistry. The methodology to be investigated is a mixture of chemistry developed at Mancheser and by others within the group. The results of the initial study will be used to complete the synthesis of biologically active compounds, lactacystin in particular.A set of experiments is designed to investigate the enzymatic desymmetrisabon of geminal diesters derived from the partial reduction of heterocycles; this chemistry should allow us to prepare useful compounds in enantiopure form wthout recourse to chiral auxiliaries.Arwther strand of the collaboration involves the use of cyclic voltametry as a tool to probe the mechanism of the partial reduction process. Using this technique, we can assess the possibility of forming both radical anions and dianions from various heterocycles. The information gained from this work can be used to study, mechanism and also in a predictive sense to chart the possible outcomes of reduction of untested heterocycles. Again, collaboration with the COST D12 groupwill provide us with access to new and varied heterocylic compounds..
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.ox.ac.uk |