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Details of Grant 

EPSRC Reference: GR/R61581/01
Title: Optimal decision-making technology for biocatalytic process network synthesis
Principal Investigator: Linke, Dr P
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Engineering and Physical Sciences
Organisation: University of Surrey
Scheme: Fast Stream
Starts: 02 January 2002 Ends: 01 January 2005 Value (£): 63,170
EPSRC Research Topic Classifications:
Catalysis & Applied Catalysis Design of Process systems
EPSRC Industrial Sector Classifications:
Chemicals No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
The development of novel decision support technology is proposed that will enable the design engineer to systematically derive optimal reaction process structures for biocatalytic systems. The technology will extend the applicability of optimisation-based process design techniques to integrated biocatalytic reaction and separation systems. Capitalising on previous experience of reaction-separation process synthesis and optimisation, a modelling and stochastic optimisation framework will be developed that captures and systematically exploits the process trade-offs and layouts in general biocatalytic systems. The technology enables the search of wide information bases and will have the potential to identify novel process structures with significantly enhanced performance charcteristics.The design problem will be addressed following a two-stage strategy so as to overcome numerical problems and the limitations of available optimisation technologies. In a first conceptual targeting stage, the exploration of a phenomena-based process supermodel will provide a quick determination of the systems' performance limits and insights into the dominant process characteristics. Building upon this conceptual knowledge, the process selection stage will exploit tailored process-unit based superstructures to develop high-performance process design candidates. Both stages allow for extensive user-interaction in the form of constraints on prohibitive scenarios and operational regimes to ensure the selection of practical high performance designs.
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Organisation Website: http://www.surrey.ac.uk