| EPSRC Reference: |
GR/R74789/01 |
| Title: |
Mathematical Modelling of Dynamic Capillary Growth and Vascular Perfusion of Chemotherapy Treatments |
| Principal Investigator: |
McDougall, Professor S |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Institute Of Petroleum Engineering |
| Organisation: |
Heriot-Watt University |
| Scheme: |
Fast Stream |
| Starts: |
22 April 2002 |
Ends: |
21 October 2003 |
Value (£): |
62,675
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| EPSRC Research Topic Classifications: |
| Animal & human physiology |
Medical science & disease |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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The aim of this project is to develop a mathematical model of dynamic pathological angiogenesis that incorporates a number of novel feedback mechanisms associated with blood perfusion through the developing capillary network. New models will be developed to produce dynamic threedimensional structures that evolve both spatially and temporally in response to a variety of different physico-chemical stimuli.As a first step, mathematical and numerical models will be developed to examine issues of non-Newtonian flow at the capillary scale; more specifically, my co-investigators and I will develop local models that capture the nonlinear correlations of blood viscosity with haematocrit, capillary radius, and shear rate. Such viscosity effects impact upon the shear stresses developed at the capillary wall and these, in turn, affect the release of various cytokines vasodilation may result and this phenomenon will also be examined using our model.Having incorporated blood flow into our vascular networks, the evolution of anti-angiogenesis and chemotherapy drugs will be followed as they pass through the capillary bed. This will afford valuable insights into the effects of network structure and microcirculation physiology upon the efficacy of drug delivery to diseased tissue under both continous infusion and bolus injection regimes
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.hw.ac.uk |