| EPSRC Reference: |
GR/R81183/01 |
| Title: |
Regioselective Design of New Ferrocene and Other Sandwich Complexes Using Inverse Crown Chemistry |
| Principal Investigator: |
Mulvey, Professor R |
| Other Investigators: |
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| Department: |
Pure and Applied Chemistry |
| Organisation: |
University of Strathclyde |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2002 |
Ends: |
31 January 2006 |
Value (£): |
220,956
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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In a recent breakthrough in our laboratory we successfully abstracted four hydrogen atoms from ferrocene regioselectively in a simple one-pot reaction, which has no precedent in the fifty years of metallocene research. This was accomplished using the encapsulating action of a 16-membered tetrasodium-tetramagnesium amide polycationic ring, the newest member of the so called inverse crown family. Since the anion-encapsulating reactivity of mixed-metal inverse crown rings is template-controlled, the reactions cannot be replicated by conventional organometallic reagents. Here we plan to exploit this 1,1',3,3' - tetraanion of ferrocene as a novel synthetic tool for designing new ferrocene-based molecules. By subjecting it to a wide range of electrophiles we aim to graft almost any type of functionalisation onto the ferrocenyl backbone. This will have major repercussions for ferrocene-based research, which covers a myriad of academic and technological interests. An open inverse crown containing three joined ferrocenyl units (a trinuclear ferrocenophane) will be put through a similar electrophilic screening programme. We also plan to transform other metallocenes and related sandwich complexes into inverse crown derivatives using the same mixed-metal amide strategy as that successfully employed for ferrocene. Target molecules in this regard include bis(benzene) chromium, (benzene) chromium (tricarbonyl) and substituted derivatives thereof.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.strath.ac.uk |