Details of Grant 

EPSRC Reference:	GR/R81367/01
Title:	Modelling and Simulation of Cardiovascular and Dermal in vitro Tissue Engineering using Finite Volume Method
Principal Investigator:	Chaudhuri, Professor JB
Other Investigators:	Horrocks, Professor M Mileham, Professor A
Researcher Co-Investigators:	Dr CS Kirk
Project Partners:	Physiome Sciences
Department:	Chemical Engineering
Organisation:	University of Bath
Scheme:	Standard Research (Pre-FEC)
Starts:	01 March 2002	Ends:	28 February 2003	Value (£):	54,018
EPSRC Research Topic Classifications:	Tissue Engineering
EPSRC Industrial Sector Classifications:	Healthcare
Related Grants:
Panel History:
Summary on Grant Application Form
Current research at Bath, focuses on the development of tissue engineered dermal and small-diameter vascular replacements, for treatment of skin ulcers and peripheral vascular disease. It is essential that vascular replacements have a sufficiently robust growth of tissue for a biologically functional material that can withstand the hydrodynamic forces encountered during transplantation. Growth of such tissue cultures use bioreactors that have been designed and constructed specifically for both types of tissue replacements and include a flat plate reactor that allows independent media feeding and environmental control on both the up- and downstream surfaces of the construct for the dermal replacement (fibroblast cells) and a tubular reactor in which the vascular graft is subjected to pulsed media flow through the lumen of the graft, thus conditioning the endothelial cells to the shear forces found in vivo. It is considered that these research programmes would benefit profoundly from computer simulation of the diffusion, adsorption and growth rates occurring in these cultivation systems thereby enhancing the design capability and functionality of bio-reactors. This will enable improvement in patient care through reduction in time to surgery and an improved in vitro cultivation method which more closely resembles that of the in vivo condition. It is considered that improvements in the predictive capability of process control, such as the control of oxygen (critical) and nutrient adsorption are vital to maintain progress of advancements in this internationally leading research.
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Organisation Website:	http://www.bath.ac.uk