| EPSRC Reference: |
GR/R89127/01 |
| Title: |
Cumulative and Temporal Analysis of Multiple Co-Released Neurotransmitters |
| Principal Investigator: |
O'Hare, Dr D |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Bioengineering |
| Organisation: |
Imperial College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2002 |
Ends: |
30 September 2005 |
Value (£): |
268,774
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| EPSRC Research Topic Classifications: |
| Biomedical neuroscience |
Instrumentation Eng. & Dev. |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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All neurones signal to each other using complex coctails of neurotransmitters. It is as yet unclear why neurones utilise multiple signalling molecules because og our lack of suitable technology for measuring their in vivo in real time. Previous work carried out by one of the investigators has shown that neurones are capable of altering the composition of the signalling molecules that they release in response to various stimuli and, most importantly, with ageing.We will use recent developments in microfabrication technologyh to develop a multi-analyte sensor to investigate how the relative concentration of signalling molecules changes under the physiologically relevant conditions. Intially the problem will be evaluated in vitro against exiting cumalative measurement techniques. the principal aim of this project, however, is simltaneously to measure patterns of release of the different neurotransmitters, the gaseoius transmiiters NO monamine 5-HT, in vivo and to extract frequency information on their relationships using the novel signal processing technique, empirical mode decomposition.. We will also develop enzyme-based sensors for the real-time measurement of the peptidergic neurotransmitter, myomodulin. It is anticipated that the methodoliges developed will be transferrable to other neuronal systems and will increase our understanding of synaptic plasticity and cellular communication and changes with ageing.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.imperial.ac.uk |