| EPSRC Reference: |
GR/R92455/01 |
| Title: |
Sequential adaptive designs for multi-treatment clinical trials with prognostic factors |
| Principal Investigator: |
Coad, Dr D |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Sch of Mathematical & Physical Sciences |
| Organisation: |
University of Sussex |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
29 April 2002 |
Ends: |
28 July 2002 |
Value (£): |
2,409
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| EPSRC Research Topic Classifications: |
| Statistics & Appl. Probability |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The project consists of two parts: Adaptive designs for comparing K>2 treatments with prognostic factors and Sequential adaptive designs for comparing K>2 treatments . In the first part of the project, an adaptive design which incorporates covariate information will be developed for comparing K>2 treatments with continuous responses. The aim is to extend the two-treatment fixed-sample design of Bandyopadhyay & Biswas (2001, Biometrika, 88, 409-419). In the second part of the project, an elimination procedure will be incorporated in the above multi-treatment design, so that less promising treatments may be dropped during the course of the trial. This work will show that the combination of the sequential and adaptive approaches can yield an effective design in terms of reducing the numbers of patients on inferior treatments, as has been shown in the two-treatment case by Coad & Rosenberger (1999, Statist. Med., 18, 761769). Designs of the type being studied are of direct relevance to pharmaceutical experimentation.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.sussex.ac.uk |