| EPSRC Reference: |
GR/R94091/01 |
| Title: |
ROPA: Reverse-Cope cyclisations using anomeric hydroxylamines |
| Principal Investigator: |
Knight, Professor DW |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
Cardiff University |
| Scheme: |
ROPA |
| Starts: |
16 June 2003 |
Ends: |
15 June 2004 |
Value (£): |
54,051
|
| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
|
|
| EPSRC Industrial Sector Classifications: |
| Chemicals |
No relevance to Underpinning Sectors |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
The central theme of these proposals is to investigate the scope of version of the reverse-Cope cyclisation wherin the necessary hydroxylamine function is generated by intramolecular addition of an alcohol group to either a nitrone or an oxime, effectively producing an 'anomeric' hydroxylamine. Reverse-Cope cyclisation will then generate bicyclic systems, most likely in a highly stereocontrolled fashion, which have potential as precursors to pyrrolidines, tetrahydrofurans and azabicyclic systems. The effects of variations in precursors ring sizes and of substituents, both peripheral and on the reacting alkene function will be a primary interest.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.cf.ac.uk |