Details of Grant 

EPSRC Reference:	GR/R96835/01
Title:	Concise Syntheses of Fluoroanalogues of Cyclitols and Sugars
Principal Investigator:	Percy, Professor JM
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	University of Leicester
Scheme:	Standard Research (Pre-FEC)
Starts:	01 April 2003	Ends:	31 March 2006	Value (£):	277,108
EPSRC Research Topic Classifications:	Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	Chemicals Pharmaceuticals and Biotechnology No relevance to Underpinning Sectors
Related Grants:
Panel History:
Summary on Grant Application Form
Allyl ethers of trifluoroethanol undergo dehydrofluorination/metallation to afford difluoroalkenylmetals which can be trapped with alpha, beta-unsatu rate aldehydes to afford difluorinated dienols. A tandem process involving Claisen rearrangement followed by reduction, affords highly-functionalised 1,7octadienes which can be converted to mono- or difluorinated cyclohexenes via ring-closing metathesis (RCM). The proposed sequences offer high levels of stereocontrol and the prospect of the availability of diverse arrays of novel cyclitol and monosaccharide analogues. The sequences are shor minimise the use of protecting group chemistry and use readily-available and inexpensive starting materials. The products include analogues of monosaccharides, and of cyclitols or carbasugars.
Key Findings
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Further Information:
Organisation Website:	http://www.le.ac.uk