| EPSRC Reference: |
GR/R97368/01 |
| Title: |
Pseudo-likelihood statistical inference from bursts of single ion channel openings |
| Principal Investigator: |
Ball, Professor FG |
| Other Investigators: |
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| Department: |
Sch of Mathematical Sciences |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 May 2002 |
Ends: |
30 November 2002 |
Value (£): |
7,565
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| EPSRC Research Topic Classifications: |
| Statistics & Appl. Probability |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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A single ion channel is usually modelled by a finite state space continuous time Markov chain. The state space is partitioned into conductance clas and it is possible to observe only which conductance class the channel is in. Short sojourns of the channel in any conductance class may be undetected. This phenomenon, which is known as time interval omission, hampers inferences concerning ion channel gating mechanisms from observed single channel recordings.In many single channel experiments, it has been observed that single channel recordings show periods of repetitive open channel activity, known a bursts, which are noticeably separated from each other by periods of inactivity. The aim of the proposed research is (i) to develop pseudo-likelihoo based methods for estimating single channel gating parameters, which are based on properties of bursts (such as total charge transfer) and are rot to time interval omission; and (ii) to apply these methods to MscL (mechanosensitive channel of large conductance) recordings.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |