| EPSRC Reference: |
GR/S00415/01 |
| Title: |
Continuation of The Synthesis of Transition State Analogues as Potential Glycosyltransferase Inhibitors |
| Principal Investigator: |
Davis, Professor B |
| Other Investigators: |
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| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
19 September 2002 |
Ends: |
18 December 2002 |
Value (£): |
13,909
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The specific inhibition of glycosyltransferases provides valuable mechanistic information about the mode of action of these poorly understood enzymes and is a potential therapeutic strategy in the treatment of disease. The structures and syntheses of several tricomponent polyhydroxylated nitrogen hetereocycles as transition-state analogue inhibitors of the action of rhamnosyltransferases are proposed. Such inihibitors represent potential agents for the treatment of TB. As a consequence of its blockwise nature this methodology is highly flexible and therefore is also applicable to the synthesis of inhibitors of other glycosyltransferases that are mediators in the mechanisms of disease.This 3-month proposal completes a previous FastTrack grant that was cut short by the successful employment of the PDRA concerned.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ox.ac.uk |