| EPSRC Reference: |
GR/S04284/01 |
| Title: |
Chiral atropisomeric DMAPs as catalysts for asymmetric acylation of alcohols and amines |
| Principal Investigator: |
Spivey, Professor A |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
Imperial College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
16 June 2003 |
Ends: |
15 August 2006 |
Value (£): |
194,587
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Catalysis & Applied Catalysis |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Food and Drink |
| Healthcare |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Over the last 20 years or so, asymmetric acylation using enzymatic catalysis has proved to be one of the most important methods in asymmetric synthesis. However, there are many drawbacks associated with the use of enzymes on both a laboratory and industrial scale, particularly the very delicate nature of most enzymes and the narrow reaction parameters within which they operate. Consequently, there is a great need for the development of robust, non-enzymatic catalysts which can perform the tasks for which enzymes are currently used. The kind of chiral compounds produced in these applications are of recognised importance as constituents of new pharmaceuticals, agrochemicals, neutraceuticals, fragrances, and 'smart' materials.The program of research described is designed to transform some exciting preliminary results that we have obtained in the development of such non-enzymatic catalysts into a robust practical technique with wide scope for the preparation of enantiomerically enriched compounds. In particular it is planned to optimise the performance of the catalysts for a wide range of potential applications and to develop efficient methods for the preparation of the catalysts in enantiomerically pure form both as solution phase catalstst and polymer-bound variants. That both enantiomers are readily available is a significant advantage over enzyme catalysts which are invariably available from nature in just one enantiomeric form.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.imperial.ac.uk |