Details of Grant 

EPSRC Reference:	GR/S05144/01
Title:	High-Resolution Mass Spectrometer for The University of Manchester Department of Chemistry
Principal Investigator:	Thomas, Professor EJ
Other Investigators:	O'Brien, Professor P Sutherland, Professor J
Researcher Co-Investigators:	Dr J Barber Professor J Clayden Dr BJ Coe Dr D Collison Professor K Douglas Professor S Faulkner Dr S Freeman Dr A Gize Professor P Hodge Professor J Joule Dr P Quayle Dr A REGAN Dr C Watt Dr R Whitehead Professor RE Winpenny
Project Partners:
Department:	Chemistry
Organisation:	University of Manchester, The
Scheme:	Standard Research (Pre-FEC)
Starts:	01 May 2003	Ends:	30 April 2006	Value (£):	449,339
EPSRC Research Topic Classifications:	Chemical Biology Chemical Structure Chemical Synthetic Methodology Combinatorial Chemistry Materials Synthesis & Growth
EPSRC Industrial Sector Classifications:	No relevance to Underpinning Sectors
Related Grants:
Panel History:
Summary on Grant Application Form
The research work which would be supported, detailed in full in Part 2 of the Application, includes the total synthesis of biologically important natural products such as the phomactins and the bryostatins, kainoids, marine alkaloids, molybdoenzyme cofactors, fluorinated enzyme inhibitors, and organometallic complexes for 'molecular electronics'; synthetic methodological investigations of various metal compounds, including those of tin and copper; mechanistic studies of non-biaryl atropisomers and crown-ether catalysts. On the analytical side, the proposed machine would support assessment of antagonists of D-myo-Ins(3,4,5,6)P4 and agonists of D-myo-Ins(1,4,5,6)P4 which are of potential benefit to CF patients, studies on prebiotic chemistry, random mutagenesis looking for a variant enzymes, structural analysis of heteropolymetallic paramagnetic co-ordination clusters and polymetallic cages, the flux of nutrient elements among mineral substrata, polar lipids for bacterial chemotaxonomy, time-resolved bioassays utilising ytterbium and neodymium complexes, 'living' free radical polymerisation using the RAFT technique, fossil fuel reservoirs, migration pathways in reservoirs and leakages from these reservoirs, and quantification of plasma levels of drugs and their major metabolites.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk Summary Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:
Further Information:
Organisation Website:	http://www.man.ac.uk