Details of Grant 

EPSRC Reference:	GR/S10162/01
Title:	FROM CRYSTALS TO CURES, PART II : ADVANCED STRATEGIES FOR SOLVING DRUG STRUCTURES FROM LABORATORY XRPD DATA
Principal Investigator:	Florence, Professor AJ
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Inst of Pharmacy and Biomedical Sci
Organisation:	University of Strathclyde
Scheme:	Standard Research (Pre-FEC)
Starts:	25 April 2003	Ends:	24 April 2006	Value (£):	45,833
EPSRC Research Topic Classifications:	Biological & Medicinal Chem. Chemical Structure
EPSRC Industrial Sector Classifications:	Chemicals Pharmaceuticals and Biotechnology Information Technologies
Related Grants:
Panel History:
Summary on Grant Application Form
This proposal centres on enabling low-temperature laboratory X-ray powder diffraction (XRDP) data collectionstrategies which are already established at the proof of concept stage, but which are neither routine nor widely applied. The general aim is to develop these strategies systematically with a view to bridging the gap between conception and routine implementation in the laboratory. More specifically, this Application is for the purchase of an Oxford Cryostream 700 series' low-temperature cooling attachment for the Bruker-AXS D8 powder X-ray diffractometer located at Strathclyde. The low-T equipment requested will enable multiple temperature experiments to be performed routinely and thereby facilitate the retrieval of an immense amount of accurate intensity data from a diffraction pattern. The data will underpin the development of optimised protocols to maximise the probability of solving complex drug crystal structures from laboratory XRPD data. For a 'philosophy' consisting of cutting-edge XRDP data collection and analysis strategies to be fully embraced by pharmaceutical industry and academia alike, it must be accessible within the laboratory environment. The program of work proposed here drectly addresses this issue and thus targets a wide range of solid-state problems of key significance to the pharmaceutical industry. The on-going development of this field and its application to solid-state problems is crucial to maintaining pharmaceutical industry's history of improving quality-of-life and creating wealth through the development of valuable drug compounds.
Key Findings
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Organisation Website:	http://www.strath.ac.uk