| EPSRC Reference: |
GR/S19929/01 |
| Title: |
Synthesis of Bioactive Marine Macrolides: Peloruside A and Reidispongiolide A |
| Principal Investigator: |
Paterson, Professor I |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Cambridge |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 May 2003 |
Ends: |
31 October 2006 |
Value (£): |
246,498
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Healthcare |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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| Related Grants: |
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Summary on Grant Application Form |
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Peloruside A, isolated from a New Zealand sponge, is a potent inhibitor of cell proliferation at the nanomolar level, causing cell cycle arrest at the G2/M phase, and inducing apoptosis. By sharing the same microtubule-stabilising mechanism as the clinically important anticancer drug, Taxol, peloruside A joins an elite group of natural products (including discodermolide, the epothilones, eleuthorobin and laulimalide) as potential chemotherapeutic agents for the treatment of solid tumours (such as breast, ovarian and colorectal cancers). Reidispongiolide A, isolated from a New Caledonian sponge, is a potent antimicrofilament agent and is active against (P-glycoprotein-mediated) multi-drug resistant cancer cells. By exploiting novel methods of substrate and reagent based stereocontrol, this research programme will focus on developing a flexible synthesis of the 16-membered macrolide, peloruside A, along with conducting studies towards the synthesis of the 26-membered macrolide, reidispongiolide A, in order to establish their absolute configurations and to enable further preclinical biological evaluation.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cam.ac.uk |