| EPSRC Reference: |
GR/S23612/01 |
| Title: |
Basic Technology: Hyperpolarised technologies for medical and materials sciences |
| Principal Investigator: |
Leach, Professor MO |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Division of Radiotherapy and Imaging |
| Organisation: |
Institute of Cancer Research |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
29 September 2003 |
Ends: |
28 March 2007 |
Value (£): |
501,385
|
| EPSRC Research Topic Classifications: |
| Analytical Science |
Chemical Structure |
|
| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
|
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
We will bring together established U.K. research communities in magnetic resonance, semi-conductors and neutron scattering to develop and enhance technologies for hyperpolarising materials and for storage and transport of these materials. We will explore the possibility of devising novel technique transferring the polarisation to other materials of interest, such as biopolymers or C in biomolecules. All of the technologies to be developed in this proposal should lead to a sensitivity improvement of up to 10, allowing a proportional reduction in sample size for analysis (i.e. microsamples even to the nanor level). Novel possibilities for nuclear magnetic resonance structure analysis of minute samples of non-crystalline, and possibly also membrane-bound, pro has enormous implications for example in post-genome studies where elucidation of the structures of 1000s of membrane-bound proteins of biological clinical interest is needed. The applications of these novel technologies to solid state analysis, of e.g. polymers and porous materials, should prove h relevant to innovative UK industries, such as in oil exploration and pharmaceuticals. The development of this generic hyperpolarisation technology will enable a whole new class of instrumentation for neutron spin polarisation analysis to be designed, and will provide enhanced signals (sensitivity, speed resolution) for many aspects of medical imaging.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.icr.ac.uk |