| EPSRC Reference: |
GR/S24121/01 |
| Title: |
The role of physico-chemical properties of excipient particles on interactions in carrier-based formulations |
| Principal Investigator: |
Price, Professor R |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Pharmacy and Pharmacology |
| Organisation: |
University of Bath |
| Scheme: |
First Grant Scheme Pre-FEC |
| Starts: |
29 September 2003 |
Ends: |
28 September 2005 |
Value (£): |
123,228
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| EPSRC Research Topic Classifications: |
| Carbohydrate Chemistry |
Drug Formulation & Delivery |
| Surfaces & Interfaces |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
| R&D |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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A variety of surface specific techniques will be utilised to determine the structure, chemistry and energetics of individual crystal faces of a whole range of carbohydrate based pharmaceutical excipients. Once characterised, selected excipients and their most suitable crystalline faces will be examined as potential candidates for modifying and controlling the adhesive interactions between drug and excipient within a carrier based dry powder inhaler (DPI) formulation. Detailed measurements of the adhesive properties of a variety of drug-excipient combinations will provide a fundamental insight into the nanoscopic interactions that govern bulk properties of a dry powder formulation and a means of selecting and modelling the face specific surface properties of individual crystal faces to the adhesive and surface properties of model drug particles. These novel excipient crystals, in which the specific surface properties are well defined, will provide a bridge between investigations for new industrial excipient particles for carrier based DPI formulations and fundamental studies of the surface specific properties which govern inter-particulate interactions.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bath.ac.uk |