| EPSRC Reference: |
GR/S40619/01 |
| Title: |
Bismuthate: a Neglected Non-Toxic Reagent for Catalytic Oxidation Reactions |
| Principal Investigator: |
Barrett, Professor T |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Imperial College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 November 2003 |
Ends: |
31 December 2006 |
Value (£): |
208,201
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Food and Drink |
| Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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The applicant will seek to develop new reactions using non-toxic bismuth(V) reagents for the oxidation or amination of benzylic methyl, methylene andmethine centres and for the conversion of alkenes into oxygenated or aminated derivatives. The study will focus on the solubilisation of bismuthate(V)salts to enhance their reactivity in organic or fluorous phase media. This will be effected by formation of complexes of potassium bismuthate with 18-crown-6 or through the use of quaternary ammonium phase transfer catalysts. The study will tie extended to the development of catalytic cyclesdependent upon bismuth(V) arid bismuth(III) using peroxide derivatives as the stoichiometric oxidant. Novel imido bismuth(V) reagents examinedfor allylic and benzylic amination reactions. These transformations will be of considerable value in the scale up synthesis of aromatic aldehydes, ketonesand carboxylic acid derivatives and of benzylic and allylic alcohols and amine derivatives without recourse to potassium permanganate, chlorine or otherhazardous reagents. Several of the reagents introduced will ultimately have the potential for immobilisation thereby enhancing the economics of theprocess and the minimisation of the waste generated in the application of these oxidation reactions.
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Key Findings |
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.imperial.ac.uk |