| EPSRC Reference: |
GR/S40640/01 |
| Title: |
Development of recoupling techniques in solid-state NMR |
| Principal Investigator: |
Levitt, Professor MH |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Southampton |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2003 |
Ends: |
31 March 2007 |
Value (£): |
278,161
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Chemical Structure |
| Condensed Matter Physics |
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| EPSRC Industrial Sector Classifications: |
| Manufacturing |
Chemicals |
| Pharmaceuticals and Biotechnology |
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| Panel History: |
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Summary on Grant Application Form |
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Describe the proposed research in about 200 words.Solid-state NMR (nuclear magnetic resonance) is capable of addressing molecular structural problems which are difficult to access any other way. For example, it is possible to use solid-state NMR measurements to estimate the dipole-dipole couplings, and hence distances, between neighbouring magnetic nuclei. This allows solid-state NMR to obtain high-resolution local molecular structural information on non-crystalline molecular systems such as ceramics, glasses, fibres, and membrane proteins, often with an accuracy of a few picometres. Unfortunately, many such solid-state NMR methods are not sufficiently robust, for example when the nuclei are relatively far from each other, or experience large chemical shift interactions or radio-frequency field imperfections, or when the nuclei involved have electric quadrupole interactions. The aim of this proposal is to apply a symmetry theory invented in our group to develop solid-state recoupling methods which are more robust, precise, and reliable, particularly at medium to long-range distances. One application of quadrupolar spin recoupling is to study hydrogen bonding between 17 O and 1H nuclei. The broad aim is to provide the community with new tools for the investigation of molecular structure on those scientifically and technologically important materials which do not yield high-quality diffraction data.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.soton.ac.uk |