| EPSRC Reference: |
GR/S40961/01 |
| Title: |
Cu-containing heterometallic complexes as novel green catalysts for carbonylation reactions |
| Principal Investigator: |
Duhme-Klair, Professor A |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
University of York |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2003 |
Ends: |
30 September 2006 |
Value (£): |
101,830
|
| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Bioprocess Engineering |
| Chemical Synthetic Methodology |
|
|
| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
This proposal targets, for the first time, the development of heterometallic copper containing complexes as green catalysts for carbonylation reactions. The work is inspired by the recent discovery of copper as a key component of the heterometallic enzyme active sites of carbon monoxide dehydrogenase and acetyl-CoA synthase. These enzymes are able to catalyse reactions that are similar to industrial carbonylation processes under very mild conditions due to a co-operative or successive interaction of different metal centres. Both enzymes contain a a sulfur bound Cu-centre as the most likely binding site for CO and a second metal centre (Mo or Ni) to provide the nucleophile. This modular structure of the active sites allows the use of exploratory combinatorial techniques to identify suitable building blocks and reaction sequences in the search for active catalysts. By using bioinspired metal combinations in heterometallic catalysts, we aim to improve the energy and atom efficiency of carbonylation processes and intend to lower the cost, toxicity and environmental impact of the catalysts used.Keywords: Catalysis, biomimetics, heterometallic activation
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.york.ac.uk |