| EPSRC Reference: |
GR/S41951/01 |
| Title: |
The radical-polar crossover reaction: optimisation of catalysis and extension to aliphatic precursors |
| Principal Investigator: |
Murphy, Professor JA |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Pure and Applied Chemistry |
| Organisation: |
University of Strathclyde |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 September 2003 |
Ends: |
31 August 2006 |
Value (£): |
228,858
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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The Radical -Polar Crossover Reaction was developed in my laboratories. It is a new and successful methodology for making C-C bonds by radical chemistry, and selectively functionalising the product in an oxidative manner. It is catalytic, and obviates the use of toxic tin reagents for radical generation.Until now, the reaction has only been applied to arenediazonium salts as substrates. This submission proposes (i) to optimise the catalytic power of the reaction with arenediazonium salts, (ii) to extend the scope of the reaction to include aliphatic substrates using new radical-polar crossover catalysts; this could have significant applications to radical and non-radical reactions alike. We propose a clean and catalytic alternative to the Friedel-Crafts alkylation and acylation reactions, as well as reactions equivalent to radical atom-transfer reactions that are currently achieved with toxic tin reagents. Many of these current processes pose major environmental problems.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.strath.ac.uk |