| EPSRC Reference: |
GR/S47403/01 |
| Title: |
A New Probe of Fundamental Weak Hydrogen Bonds: Solid-State NMR |
| Principal Investigator: |
Brown, Professor SP |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Physics |
| Organisation: |
University of Warwick |
| Scheme: |
First Grant Scheme Pre-FEC |
| Starts: |
01 April 2004 |
Ends: |
30 June 2006 |
Value (£): |
122,769
|
| EPSRC Research Topic Classifications: |
| Analytical Science |
Chemical Structure |
|
| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
There is growing interest in so-called weak hydrogen bonds of the type C-H..X and X-H..pi because of their importance in crystal engineering, molecular recognition and supramolecular chemistry, as well as protein-ligand complexes and enzyme action in biological systems. These interactions are, by nature, weak and, therefore, difficult to detect. Advanced analytical methods capable of probing them are, thus, required. The overall aim of the proposed research is to demonstrate the suitability of solid-state NMR as a probe of weak hydrogen bonds. Solid-state NMR is a well-established pr of conventional hydrogen bonding and can provide information that is complementary to that available from other methods, e.g. crystallography. In particular, 1 H solid-state NMR can focus in on the most important part of a hydrogen bond, namely the proton. Specific aims include (i) the observation of J couplings across weak hydrogen bonds which would provide direct evidence for the presence of such a bond, (ii) the measurement of dipolar couplings between hydrogen-bonding partners in order to determine hydrogen-bonding distances and also investigate whether weak hydrogen bondi restricts the dynamics of, e.g., methyl groups, (iii) the quantification of the effect of weak hydrogen bonding on the 1 H chemical shift
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.warwick.ac.uk |