EPSRC Reference: |
GR/S58508/01 |
Title: |
Organocatalytic Asymmetric Aziridination of Alkenes |
Principal Investigator: |
Armstrong, Professor A |
Other Investigators: |
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Researcher Co-Investigators: |
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Project Partners: |
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Department: |
Chemistry |
Organisation: |
Imperial College London |
Scheme: |
Standard Research (Pre-FEC) |
Starts: |
04 October 2003 |
Ends: |
03 October 2006 |
Value (£): |
222,418
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EPSRC Research Topic Classifications: |
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EPSRC Industrial Sector Classifications: |
Chemicals |
Pharmaceuticals and Biotechnology |
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Related Grants: |
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Panel History: |
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Summary on Grant Application Form |
Aziridines are potentially highly valuable synthetic intermediates, since they can undergo ring opening with a range of nucleophiles. Asymmetric aziridination of alkenes would provide a direct method for the preparation of chiral aziridines, but existing methods are inefficient or give good enantioselectivities for a limited range of alkene types. This project aims to develop general, efficient methods for asymmetric alkene aziridination catalysed by small organic molecules. This approach, recently termed organocatalysis, offers advantages over metal-catalysed processes in terms of ease of product purification and rationalisation of modes of asymmetric induction.This project will investigate several aziridination processes mediated by small organic molecules. We will attempt the in situ preparation of oxaziridines from electron-poor ketones as a potential ketone-catalysed aziridination procedure. We will also explore the formation and chemistry of diaziridinium salts as aziridinating agents. Aminimines form a further interesting class of nitrogen transfer reagent, and we will examine both stoichiometric and catalytic procedures. For all methods, substrate scope in terms of alkene electronics and substitution pattern will be investigated.
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Key Findings |
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Potential use in non-academic contexts |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
Summary |
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Date Materialised |
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Sectors submitted by the Researcher |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Project URL: |
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Further Information: |
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Organisation Website: |
http://www.imperial.ac.uk |