| EPSRC Reference: |
GR/S61287/01 |
| Title: |
Engineering colloidal systems to develop solubility enhancing technology |
| Principal Investigator: |
Perrie, Professor Y |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Life and Health Sciences |
| Organisation: |
Aston University |
| Scheme: |
First Grant Scheme Pre-FEC |
| Starts: |
01 October 2004 |
Ends: |
31 January 2008 |
Value (£): |
80,956
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Complex fluids & soft solids |
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| Panel History: |
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Summary on Grant Application Form |
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Many small molecule (-500 Da) drugs tend to have limited solubility eg <1.5mg/ml. In order to achieve therapeutic efficiency these compounds require solubility enhancement through formulation engineering. This project will employ colloidal surfactant-based systems to enhance the solubility and delivery of poorly soluble drugs. Despite numerous investigations into the application of colloidal surfactant vesicles (eg. lipsomes and niosomes) for the delivery of hydrophilic drugs, their application as solubilising agents has received limited attention. However these systems, due to their diversity in design, composition and construction, offer a dynamic and adaptable technology for enhancing drug solubility. The aim of this project is to develop formulation and construction protocols for designing surfactant vesicle-based solubility enhancing technology. To understand the mechanistic processes involved in the construction of these solubilisation vectors a systematic examination into the influence of vesicle design and composition on structural (vesicle size, morphology) and physico-chemical (eg drug payload and retention, bilayer characteristics) properties will be performed. Results from these investigations will not only define the parameters controlling inclusion of solutes within these surfactant vesicles, but will also provide the knowledge to effective design and manufacture vectors which can improve the delivery of these therapeutic molecules based on their molecular characteristics.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.aston.ac.uk |