| EPSRC Reference: |
GR/S64134/01 |
| Title: |
Nanostructured assemblies for the detection of biological agents |
| Principal Investigator: |
Russell, Professor D |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of East Anglia |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 February 2004 |
Ends: |
31 July 2007 |
Value (£): |
219,051
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Chemical Biology |
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| EPSRC Industrial Sector Classifications: |
| Aerospace, Defence and Marine |
Healthcare |
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| Panel History: |
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Summary on Grant Application Form |
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The aim of this research programme is to develop a generic platform technology fond the colorimetric assay of a number of biological agents based on metal nanoparticle aggregation and/or disaggregation. Metal nanoparticles will be stabilised with a self-assembled bifunctional linker monolayer. This linker will not only facilitate the formation of a monolayer structure surrounding the metal nanoparticle through a metal:sulfur bond, thereby stabilising the particles, but the second functionality will enable the attachment of ligands through simple alkyne-azide cycloaddition chemistry. The ligands to be bound will specifically bind to receptor sites of biological agents. The metal nanoparticles with bound ligands will be monodispendse in solution giving a characteristic colour. Binding the target species, via ligand-agent interaction, will induce aggregation of the metal particles with a consequent change o solution colour. The colour changes associated with dispersed-aggregated metal nanoparticles will be investigated for the development of colorimetndic assays fond a variety of ligand/agent interactions. Such assays would enable the development of a simple detection technology fond key biological agent: based on a miniaturised field instrument.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.uea.ac.uk |