| EPSRC Reference: |
GR/S71811/01 |
| Title: |
The application of tunnelling spectroscopy to the analysis of bimolecular electronics |
| Principal Investigator: |
Davis, Professor J |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 September 2004 |
Ends: |
31 August 2006 |
Value (£): |
269,640
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| EPSRC Research Topic Classifications: |
| Chemical Biology |
Electrochemical Science & Eng. |
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| EPSRC Industrial Sector Classifications: |
| Electronics |
Environment |
| Healthcare |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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The mechanisms of charge transport through biological polymers remains a subject of much debate, central to our understanding of many fundamental biological processes and to our interpretation of tunnelling images. We propose to explore the electronic properties of single metalloprotein molecules by tunnelling spectroscopic and imaging (Atomic Force Microscopy and Scanning Tunnelling Microscopy) studies under ambient and electrochemical conditions. Biomolecular tunnel junctions will be created by trapping protein molecules between the scanning probe tip and underlying substrate. The properties of these junctions under a variety of conditions will be subsequently analysed. The apparent inverse linear scaling of biomolecular conductance with pressure (preliminary and published results) will be further scrutinised with several metalloproteins. The effects of metal ion substitution on properties will be an additional focus. Results will shed light on the mechanisms of charge transport through these molecules, the speck roles of redox-active metal centres and our interpretation of biological scanning tunnelling microscopy data. Our ability to control (for example, by electrochemically switching ) the properties of biomolecular tunnelling junctions and the influence of environmental parameters on these will be examined.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ox.ac.uk |